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Further elucidation of the mitochondrial quality control pathways used to protect cells may provide potential opportunities for PD treatment in cases of mitochondrial dysfunction (Figure 1)

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

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Non-hormonal alternatives like clonidine and gabapentin are also used but may lead to adverse effects such as sleep disturbances, nausea, constipation, and dizziness (Dehghan et al., 2022)