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Quality filtered reads were mapped on assembled contigs to obtain abundance profiles, which were normalized to CPM (Counts Per Million) using EdgeR v3.10.2 35

Focusing on drug delivery at the cellular level will be key to understanding why some pharmacotherapies fail, even when bulk tumor concentrations appear sufficient to elicit a predicted response

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Its name was coined in 2012 as the discovery of small molecules (e.g., erastin and RSL3) selectively induced a non-apoptotic form of RCD in cancer cells that can be blocked by iron chelators or lipophilic antioxidants (e.g., vitamin E/-tocopherol and ferrostatin-1) (Wen et al., 2019)