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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by Pyruvate Dehydrogenase and that TCA cycle flux is diminished (Gray et al., 2015, Rauckhorst et al., 2017)

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Moreover, Natural Extracts and Innovative Products for Alternative Healthcare, and Cell Engineering for Cancer Therapy Research Groups, Chiang Mai University, Chiang Mai, Thailand were also grateful acknowledged