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Homocysteine levels should also be checked to ensure that the mother is not experiencing any other health issues associated with the MTHFR polymorphism

Meanwhile, emodin synergizes with DDP to enhance lung cancer A549/DDP cell apoptosis and impede migration/invasion, likely via inhibiting NF- B signaling and down-regulating drug resistance proteins (P-gp, MRP, and GST), thereby reversing DDP resistance and augmenting intracellular drug accumulation [483]

Excessive alcohol intake suppresses natural killer (NK) cell activity, reduces T and B cell populations, disrupts antigen presentation via the major histocompatibility complex class I (MHC-I) pathway, and diminishes production of antiviral cytokines, including interferons (IFN-/ and IFN-)

10.13705/j.issn.1671-6825.2019.12.047 36 Ghafouri-FardS.ShabestariF