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2.1.1 In vivo models Orthotopic LTx, which is more commonly performed using the left lung, has been used to study PGD and recapitulate the various steps in clinical LTx such as cold and warm ischemia as well as immunosuppression using murine models ( Another commonly used model to study lung IRI is the hilar ligation model ( 2.1.2 Ex vivo lung perfusion Ex vivo lung perfusion (EVLP) has developed as a novel method to maintain donation after cardiac death (DCD) lungs in physiologically protective conditions outside the body and allows accurate evaluation of lung function, as well as providing a new platform for therapeutic treatment and repair of damaged donor lungs before transplantation (33)

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The walls of hollow organs are usually infiltrated ( 26 )

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