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During the COVID-19 pandemic, transplant waitlist registrants increased more than 50% from pre-COVID predictions, possibly due to the increase in alcohol use disorder as well as changes in transplant center risk stratification (11, 12)

Preclinical findings suggest that supplementation with CYGB or NGB proteins can further normalize the fibrotic, hypoxic niche, enhancing immune infiltration and treatment sensitivity [27, 145]

Methods: We enrolled 436 adult participants for a single-centered prospective study in an outpatient clinic during a one-year period

Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , five times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3