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1 Time-effect curve of the control, morphine, and BPC-157 (from 10 to 40 g/kg) groups of the flinching response in the formalin test Data are presented as the number of flinching and licking/biting

Most heavy metals are able to efficiently penetrate the bloodbrain barrier and they easily substitute calcium ions during their passage through the bloodbrain barrier, thus interfering with the regulatory action of calcium on brain cells and disrupting the related intracellular activities

The role of copper in oxidative stress and inflammation Some of the molecular mechanisms underlying copper-induced depression included oxidative stress, neurotransmitter imbalance, and impaired synaptic plasticity

USA 104 , 1317013175 (2007)