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Nutrition 21 , 137141 (2005)

This is more common in women than men

Although thioredoxin is not itself imported into the ER (being an 11.6 kDa protein rather than a small tripeptide like glutathione), the pathway has been shown to influence ER lumenal redox potential, likely through the conveyance of reducing equivalents through an as-yet unknown ER-resident transmembrane protein (Poet et al., 2017)

Such studies have shown that antibiotic administration might increase the effectiveness of L-DOPA therapy, indicating that gut microorganisms affect metabolism and the effectiveness of the drug (Hashim et al., 2014)