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Perturbations to glutathione homoeostasis have also been explored in disease models

Cell 148:213227 Cai Z, Jitkaew S, Zhao J, Chiang H-C, Choksi S, Liu J, Ward Y, Wu L-g, Liu Z-G (2014) Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(See DOSAGE AND ADMINISTRATION.) Although reactions are usually evident within a few minutes, observe patients for at least one hour before administering the therapeutic dose