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The short half-life reflects rapid clearance and ligand exchange with serum proteins such as albumin and ceruloplasmin

Nursing animals and young, rapidly growing animals develop iron deficiency more easily than adults on an iron-replete diet, particularly if there is a concurrent source of external blood loss: iron stores in young animals tend to be marginal, milk is low in iron, and rapid growth demands expansion of blood volume

Additionally, we sought to demonstrate specificity of RSL3 for targeting BRAF/RAS addicted cancer cells by selecting TPC-1, a PTC cell line, that lacks RAS or BRAF mutations

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