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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

While animal-based foods are naturally rich in vitamin B12, many plant-based foods and breakfast cereals are fortified to help people meet their needs

So have too much B12, never thought I'd say that

"Not FDA-approved" just means the FDA hasn't reviewed or signed off on its safety, efficacy, dosing, or manufacturing for people