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Effects of various compounds on histidine decarboxylase activity: Active site mapping

All these steps are accompanied by the hypergastrinemia, resulting from the damage by VacA of parietal cells, hypochlorhydria and impairment of gastrin-somatostatin link with excessive release of gastrin and its CCK2-receptors in the inflamed fundic mucosa and by neoplastic cells (23, 70)

Recent advances in molecular biology and genomics have revealed complex mechanisms of tumor development, increasingly highlighting the importance of molecular markers in the diagnosis, prognostic assessment, and treatment decision-making (5)