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44,157,158 Therefore, therapeutic strategies involve ROS-inducing agents (prooxidant drugs, TRXR/GSH inhibitors), ER stress inducers, p53 reactivators, and combination therapies (e.g., with PARP inhibitors or immunotherapy)

Glutathione S-transferases (GSTs) represent an important superfamily of phase II metabolic enzymes that catalyze the conjugation of reduced glutathione with electrophilic groups of a wide variety of environmental compounds