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They also help reduce homocysteine levels, which, when elevated, can contribute to inflammation and damage to blood vessels

In the specific evaluation of fatigue, fatigue diaries and numerous scales for the clinical and neuropsychological examination are summarized in Table 1

Pochettino F, Visconti G, Godoy D, Rivarola P, Crivelli A, Puga M, et al

The phosphorylated JAKs then activate STAT proteins, which dimerize and translocate to the nucleus, where they attach to target DNA sequences and modulate gene expression 415 (Fig