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Xue Q et al., Copper-dependent autophagic degradation of GPX4 drives ferroptosis

These sterols not only inhibit proliferation of cancer cells but can also stop the growth of DMBA cancers upon direct absorption into the tumor

EBV-encoded BNRF1 membrane protein degrades the SMC5/6 complex through calpain proteolysis and the E3 ubiquitin ligase Cullin-7 dependent proteasome degradation pathway, allowing EBV to escape host restriction on viral genome replication and the production of infectious progeny virions (Yiu et al., 2022)