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Instead, oxygen has to diffuse from the closest blood vessels into the rest of the tumor, making it very difficult for oxygen to reach every single cell in the inner parts of the tumor ( Figure 1 )

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mice were immunized by an intravenous injection of 5 10 6 washed sheep red blood cells obtained weekly from Institut Armand-Frappier, Laval des Rapides, Quebec, Canada

Specific diseases caused by ABCB11 mutations: ICP, BRIC, and PFIC2 Mutations of ABCB11 encoding BSEP can give rise to a spectrum of cholestatic disorders of varying severity