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Nevertheless, contemporary research has revealed that the administration of metformin can trigger ferroptosis by counteracting the generation of lipid ROS through autophagy inhibition ( Nuclear receptor coactivator 4 (NCOA4) is a discerning receptor that upholds iron homeostasis by binding to ferritin, conveying ferritin to lysosomes, and stimulating autophagic degradation

But what about antioxidants

Corresponding to the earlier-discussed role of Zn in MT synthesis, Zn intake and Zn status in obese patients were significantly associated with peripheral blood mononuclear cell MT levels [16]

10.1080/1061186X.2017.1280809 101 SelvarajahD.KarD.KhuntiK.DaviesM