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The structural analysis clearly shows that the naphthoquinone moiety of shikonin precisely anchors the protease catalytic dyad His41-Cys145 through T-type - stacking, while its propionyl side chain occupies the S1, S2 and S4 sub-pockets, forming a unique sandwich binding configuration across the active center (Li et al

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The metabolic activity of the gut microbial flora on hormones, which controls enterohepatic recycling, iodine uptake/deterioration, and levothyroxine bioavailability, is connected to the release of TSH (Cayres et al

Age-related impairments in the dynamic regulation of active microglia by astrocytes