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References [i] Pickart, L., Thaler, M

USA 89 , 48454849 (1992)

Int J Cardiol 198:15 Johnsen SP, Hundborg HH, Srensen HT et al (2005) Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke

Limitations of animal research: Rat healing faster than human, young research animals heal better than aged humans, controlled injury models don't replicate complex human injuries perfectly, dosing conversions uncertain (body weight scaling imperfect), immune system differences affect inflammation and healing