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Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window

We adjusted for the estimated cell-type compositions as covariates in the downstream statistical analysis

The regulation of the JAK/STAT system involves numerous mechanisms, one of which is the control of JAK kinase activity phosphorylation by suppressor of cytokine signaling (SOCS) proteins (Cha et al