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Several 1,4-naphthoquinone derivatives, such as menadione 26 , -Lapachone 27 , 2-(hydroxymethyl)anthraquinone 28 , 2-methoxy-1,4-naphthoquinone 29 and synthetic 2-methylnaphtho(2,3- b )furan-4,9-dione 30 , have been reported to exhibit potent in vitro anti- H