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Similarly, Al-Nasser et al

For example, the structure of the ECM sequesters antifungal agents and slows down the diffusion of the antifungal agent to the cells of the biofilm, the efflux pumps and stress response systems in the biofilm cells are markedly upregulated

The binary gradient used was as follows: 01.0 min (016% B), 1.04.5 min (1622% B), 4.54.6 min (22100% B), 4.66.6 min (100% B), and 6.78.0 min (0% B)

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