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3 Department of Bone Injury, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, Peoples Republic of China Correspondence: Bo Wang, Department of Bone Injury, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, Peoples Republic of China, Tel +86-18646246661, Email [email protected] Abstract: Osteoarthritis (OA) is a major global contributor to pain, disability, and socioeconomic burden

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(iv) no current use of pro-convulsive drugs

A 2024 systematic review published in a peer-reviewed orthopaedic journal acknowledged these findings while flagging a critical limitation: there are no completed Phase III clinical trials in humans