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A typical four-week titration schedule for cognitive research models follows this pattern: Week 1 : 0.5mg/kg three times weekly (Monday/Wednesday/Friday) Week 2 : 1.0mg/kg three times weekly Week 3 : 1.5mg/kg three times weekly Week 4 : 2.0mg/kg three times weekly The three-day dosing interval (every 4872 hours) accounts for Dihexa's estimated half-life of 24 hours in rodent models, allowing complete clearance between doses while maintaining cumulative exposure over the study period

Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice