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Specifically, TLR1/2 recognizes triacylated lipopeptides from Gram negative bacteria (38, 39), TLR2/6 recognizes diacylated lipopeptide from mycoplasma (38, 48), and TLR2/10 recognizes microbial components shared by TLR1 (37)

While these processes are essential for maintaining hormonal balance, elevated enzyme activity can lead to excessive estrogen reabsorption and contribute to hormone-related diseases