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Controls, calibration and reporting standards Implement specificity controls (SOD, catalase/GPx mimetics, peroxiredoxin modulation, iron chelators), genetic tools (isoform knockdown/knockout, rescue) and pharmacologic orthogonality (distinct inhibitor classes)

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However, it could not address symptomatic improvement of DPN in clinical trials, but it only improved nerve conduction velocity [79,80]

doi: 10.3920/BM2014.0118 110 OkumuraS.KonishiY.NarukawaM.SugiuraY.YoshimotoS.AraiY.et al