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It has been suggested that physicians should consider screening for vitamin B 12 deficiency in diabetic patients before starting metformin therapy, and periodic monitoring of vitamin B 12 levels has been recommended for all patients using metformin, particularly for those using the medication long-term [21, 34]

Meanwhile, an other study (Gong et al., 2018) also suggested that the prognostic value of c-Met is contradictory

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