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Under hypercatabolic conditions, its levels are considerably depleted a condition that correlates with pathological severity and has been suggested as an independent predictor of mortality in intensive care unit patients

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doi: 10.7314/APJCP.2013.14.11.6245 186 KuivanenTJeskanenLKyllnenLIsakaKSaarialho-KereU

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Nature 488(7410):17811784

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