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Secondly, under drug stress, the fungus undergoes core metabolic remodeling, with the activities of glycolysis and the tricarboxylic acid cycle being downregulated, and the cells entering a low metabolism and non-proliferative dormant state, significantly reducing their sensitivity to lethal doses of antifungal drugs

Technical debt is not an option in this business where regulations are constantly changing and updating

No studies have directly evaluated the cardiovascular effects of correcting vitamin B 12 deficiency in patients with known cardiovascular disease, although numerous studies have failed to demonstrate that correction of hyperhomocysteinemia itself reduces cardiovascular mortality or cardiovascular complications

Bonnefond, A