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The datasets had already been robust multi-array average-normalized in batches using the makecdfenv, affy and limma R packages, and batch-corrected using the ComBat method in the sva R package

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Treatment may require long-term medication or invasive procedures like ablation or pacemaker implantation

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More frequent treatment is not automatically better or necessary

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Neurochem Int 53 , 395400 (2008)

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