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When NCOA4 expression is upregulated, it recognizes and binds to ferritin heavy chain 1 (FTH1) and mitochondrial ferritin (FTMT), interacting with autophagy-related factors and primary autophagosomes to form autophagosomes for lysosomal degradation, thereby releasing large amounts of Fe 2+ and forming the LIP

& Faraonio, R

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In this regard precision-cut human liver slices (PCLiS), incubated in vitro, might represent a valuable ex vivo liver model for NA testing, due to preservation of both cellular composition, the three-dimensional architecture, and liver-specific functions of the donor liver