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C.YilmazF.et al (2020)

Thus, CARN depletion may impair active tubular secretion of MTX, leading to decreased clearance and higher serum levels

Strycharz-Dudziak, M., Kieczykowska, M., Drop, B., et al

However, the latest data from the CIRT, with its negative results, imply that the inflammatory pathway is rather complex and that the adenosine-mediated anti-inflammatory effect of methotrexate might not be as effective as canakinumab at targeting IL-1