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however, the biological origin of aging-associated chronic inflammation is largely unknown

The aim of this review is to summarize the current evidence on the effects of metformin on gut microbial composition and the immune system, as well as its potential role in the treatment of skin diseases

Similarly, the glutathionylation of Cys56 leads to structural perturbations of the -helix structure, such as the canonical EF-hand (i.e., 1 helix), 3, and 4 helices of the noncanonical EF-hand and the 6 and 8 helices of the sterile- motif domain 155

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