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Introduction Definition movement disorder characterized by Parkinson-plus syndromes multiple system atrophy progressive supranuclear palsy corticobasal degeneration (CBD) Associated conditions dementia depression sleep disorders Pathogenesis Loss of dopaminergic neurons in the substantia nigra leads to dopamine depletion in the striatum this creates an imbalance between dopamine and acetylcholine resulting in improper muscle movement Impaired degradation of -synuclein can lead to degradation of dopaminergic striatal neurons Presentation bradykinesia muscle rigidity postural instability resting tremor Studies Differential Huntington disease differentiating factor Essential tremor differentiating factor Drug-induced Parkinsonism Treatment Medical Operative deep brain stimulation Complications Dementia Sleep disorders Falls Create a free account or log in to see the cards.

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1 After ingestion, intact anthocyanins are generally detected at low concentrations in circulation, while a broader range of conjugated and microbially derived metabolites (e.g., methylated, sulfated, glucuronidated forms, and smaller phenolic acids) can persist longer and may contribute to biological effects

Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ