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Medications: Some medications, including antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs), can cause an allergic reaction that leads to hives

Muscle spasms in the shoulders frequently result from rotator cuff strain, bursitis, postural overload, or referral pain from a cervical disc issue

Medications that block the inflammasome: Several medications are under study which block the inflammasome, which is a group of proteins that work together to activate IL1, among other actions