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Mariani et al transitioned 5 patients from high-potency opioids to BUP-XR after only 23 days of sublingual buprenorphine

The source of such ketone synthesis in the liver, when the body is under glucose starvation, is smart from the point of view that fatty acids themselves, originating from the bodys fat reserves, cannot cross the bloodbrain barrier and thus satisfy the brains energy needs (16, 17)

When taurine levels are low, bile acid conjugation shifts toward glycine conjugation, which produces less efficient bile salt micelles and impairs toxin excretion