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In addition to T-brachyury, expression of Sonic hedgehog ( Shh ) and hepatocyte nuclear factor ( HNF )-3 (also known as FoxA2 ) is important for successful differentiation and survival of notochordal cells (Risbud and Shapiro, 2011)

BPC-157 in inflammatory bowel disease research The most direct autoimmune application for BPC-157 involves inflammatory bowel diseases, specifically Crohn's disease and ulcerative colitis