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Medicinia Intensiva

All citations on this page refer to pre-clinical and peer-reviewed research and do not constitute a claim of safety or therapeutic efficacy

Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer

However, the upregulation of MET expression in HCC presents a challenge: Oxidative DNA damage activates MET, which interacts with and phosphorylates PARP-1 at tyrosine 907, thereby limiting the effectiveness of PARP-1 inhibitors in HCC (109)