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Moreover, it has been shown that the activation of RAAS and hyperinsulinemia may synergistically stimulate the MAPK pathway, which exerts an effect damaging to the vascular wall by inducing endothelial dysfunction and promoting atherosclerosis [113]

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"Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus"

doi: 10.1158/1538-7445.AM10-5109 137 HuaFXiaoY-YQuX-HLiS-SZhangKZhouCet al

Detoxification of electrophilic compounds by glutathione S -transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs