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Discussion Collectively, these results suggested that ACTL6A, which contains a hydrophobic region, cooperates with NRF2 to regulate GCLC expression at the transcriptional level and then promotes GSH synthesis and inhibits the ferroptosis of GC cells

How It Works Mitochondria, the powerhouses of your cells, are where ATP (energy) is produced

Low GSH levels are linked to increased vulnerability to toxins and chronic diseases, highlighting its importance in maintaining cellular health and protecting against toxic exposures (3)

However, considering that the human bodys endogenous antioxidant system is not sufficient, the human body can hardly produce nonenzymatic antioxidants, so it depends on exogenous nonenzymatic antioxidants, such as mineral elements, nutritional antioxidants, phytochemicals, cytoprotectants and synthetic compounds (Table 1) [34, 36]