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No evidence of significant cortisol elevation, prolactin disturbance, or hepatic adverse effects has been observed in available research data

Research uses it to characterise GHRHR binding with the intact full-length pharmacophore, Gs-cAMP-PKA signal transduction, and whether the C-terminal GHRH domain residues 3044 absent from all truncated GHRH analogues contribute pharmacologically meaningful differences to receptor engagement relative to Sermorelin and Modified GRF(1-29)

[11] In practice, sermorelin is almost never used during pregnancy, since treating chronic growth hormone deficiency can typically be deferred and other therapies (if needed) would be chosen if GH support was truly required