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The multi-domain therapeutic potential inferred from our surrogates should be viewed within the limitations of the scopolamine model as not replicating synaptic failure, progressive neurodegeneration, and proteinopathic features typical of AD

Previously, we demonstrated in a screening approach using FDA-approved drugs that the LIP/LAP ratio is druggable also apart from known mTORC1 inhibitors 59

J Chin Ceram Soc 45(03):327332 Song S, Li X, Ji Y, Lv R, Wu L, Wang H, Cao M, Xu Z (2021) GSH/pH dual-responsive and HA-targeting nano-carriers for effective drug delivery and controlled release[J]