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Moreover, hormonal changes with aging such as insulin resistance, lower IGF-1 levels, and higher glucocorticoid levels can tilt the balance toward a catabolic state, meaning geriatric patients often have a blunted anabolic response even with adequate nutrients [69, 70]

Similar interactions have been observed in individuals receiving various combination drug regimens such as antipsychotics or sedatives with contraceptive agents, sedatives with anticonvulsant drugs, and even alcohol with hypoglycemic drugs (tolbutamide)

Anti-Inflammatory Activity of Fisetin in Human Mast Cells (HMC-1). Pharmacological Research, vol

Further research is needed to optimize the efficacy and safety of these therapeutic strategies and to translate preclinical findings into clinical applications for individuals with COPD (116)