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But also, the opposite way is conceivable: if there is a lack of biotin, vitamin B12 cannot fulfil its function in the citrate cycle and remains unused in the tissue possibly leading to the behavioural change of the skin bacteria already discussed

Nel L, Eren E (2011) Peri-operative anaphylaxis

crucially, this aneuploidy also confers cross-tolerance to unrelated 5-flucytosine, with instability of aneuploidy leading to reversible drug tolerance (Sun et al., 2023b).Collectively, the intraspecific differences of C