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Nature 362(6415):5962 Radunovic A, Leigh PN (1996) Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features

Figure 1 summarizes the timeline for discovery, biomarker investigations, and toxicokinetic studies for selected mycotoxins

Degrees of protection have been observed following treatments with Rho kinase inhibitors, endothelin ET-2 inhibitors, erythropoietin, resveratrol, NMDA receptor antagonists, NO donors, antioxidants, 2-adrenergic agonists (brimonidine), cannabinoids (e.g., 9-THC) and -adrenergic blockers

More nanoparticles are expected to be developed to enhance effectiveness and minimize side effects in targeting endothelial dysfunction and atherosclerosis