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Escalating the dose to chase a faster result is explicitly not the studied approach

The solid form of any one of claims 38-40, having an X-ray powder diffraction pattern comprising peaks located at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1, 12, 13, 14, 15, or all of the following or approximately the following positions: 6.2, 9.0, 1 1.3, 11.7, 12.4, 12.9, 13.0, 13.4, 14.4, 14.6, 16.0, 16.8, 17.5, 18.0, 18.3, 18.6, 19.6, 19.8, 20.3, 21.3, 21.7, 22.6, 23.2, 23.5, and 24.4 degrees 2, plus or minus 0.10

In some embodiments, an LNP further comprises a 5 th lipid, besides any of the aforementioned lipid components

Reported effects with this class include mild water retention, transient tingling or numbness in the hands, a brief flushing or head-rush sensation after injection, and increased hunger with some secretagogues