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(ii) penetration into the cytoplasm and interference with cellular structures

Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine

GSH levels and their related enzyme activities, such as the activities of GPx and GR, are higher in cultured microglia than in cultured astrocytes and neurons, especially under oxidative stress conditions [85,86]

PGC-1 regulates DRP1 expression by enriching in the promoter region to downregulate DRP1 expression and further inhibits mitochondrial fission ( via deacetylating and activating OPA1 (Samant et al., 2014)