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Oxygenases, such as JMJC domain (JMJD) histone demethylases, DNA 5-methylcytosine (5mC) dioxygenases (TET1/2/3), RNA 6-methyladenine dioxygenases (ALKBH5/FTO (a fat mass and obesity-associated protein)), and lysine-specific demethylase 1/2 (LSD1/2), regulate the methylation levels of histones and RNA/DNA, which are important for generating the epigenetic landscape (Fig

Conversely, metabolites such as citric acid, aminomalonic acid, palmitoleic acid, conduritol-b-epoxide, shikimic acid, 4-hydroxyphenylacetic acid, hesperitin, anandamide, oxalacetic acid, pimelic acid, 2-ketoadipate and N-ethylmaleamic acid were upregulated (Ke et al., 2021)

When paired, researchers may examine whether the blend suggests a pattern of prolonged or layered receptor engagement across different cellular models

Taken together, our data indicate that the main mechanism by which disulfiram induces apoptosis in leukemia cells is by augmenting ROS levels and triggering oxidative stress