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Preclinical genotoxicity the signal most dosing pages have never heard of Ben-Shlomo and colleagues reported in the Journal of Clinical Investigation in 2020 that cAMP stimulation of pituitary cells including with a long-acting GHRH analogue increases GH production and concomitantly induces DNA damage in the tissue it acts on

Older adults (60+) or those with obesity, metabolic syndrome, or poor baseline health may start at 250-300mcg given their typically reduced pituitary sensitivity and response

Half-Life: ~2030 hours

Here is a quick reference for researchers: Note: Amounts above ~150 mcg do not appear to produce proportionally greater GH output in research models, likely due to GHRH receptor saturation