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The secretion of organic cations (positively charged drugs) appears to be more efficient in men than in women, leading to faster drug elimination (Nicolas et al

Skeletal muscle and heart may also accumulate considerable amounts of iron as is noted in brain, liver and other tissues, and there is evidence that increased iron storage correlates with ROS formation in tissues (Yoshiji et al., 1992

Antidepressant agents that can be considered as photostable are desipramine (ICH conditions) (Thiyagarajan et al

(2) remote ischemic perconditioning, applied during an ischemic event to activate protective mechanisms and minimize damage